Affineo

Proteins, engineered
to endure.

We evolve proteins inside an extremophile — so selection happens in the conditions the protein has to work in, not in a clean buffer.

See how it works Talk to the team

01 Our approach

We screen proteins inside
something that already lives at the edge.

Our screen runs inside a living extremophile — an organism that already tolerates the conditions we care about. Variants that can't survive simply don't make it through. The ones that do are real hits the first time you see them.

I.

Generate

Libraries of protein variants — from thousands to millions, designed against a target function.

II.

Select in vivo

The library is expressed inside our extremophile host. The environment is the selection — variants that fold and function survive; the rest don't.

III.

Discover

Hits come out already tested against the conditions they'll meet downstream. Weeks of wall-clock time, not months or years.

10k–100k
variants tested per run
2–4wk
from library to ultra-resilient leads
1
organism doing selection and expression at once

02 Current focus

Selective metal binding,
for recovery and purification.

Hydrometallurgy often has to separate ions that barely differ, and the chemistry it uses was never especially selective. Plants run many stages of solvent extraction to force the separation, or accept resins that bind the wrong thing along with the right one.

Our premise is that a protein could do better. We are building a platform to evolve metal binders inside the liquor they would have to work in, at the acidity and temperature of the plant and through the load-and-strip cycle a column actually sees. A binder that survives that selection has ignored other ions, and has let go of the target cleanly on strip.

03 Our team

Paris-based,
with shared roots in Cambridge.

Dariusz Czernecki
Science & Operations

Dariusz Czernecki

  • École Normale Supérieure
  • Sorbonne Université
  • Institut Pasteur
  • MRC Laboratory of Molecular Biology
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Maxime Crabé
Strategy & Partnerships

Maxime Crabé

  • École Polytechnique
  • University of Cambridge
  • Collège des Ingénieurs
  • Boston Consulting Group
  • Cepton Strategies
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04 Partners & programmes

Backed by the people
building deeptech in France.

Affineo is supported by Genopole — first through the Shaker programme, now through Gene.iO — and joins the latest Wilco One cohort for Foodtech & Agritech.

  • Genopole
    Biocluster · Évry
  • Shaker
    Pre-incubation · alumni
  • Gene.iO
    Incubation · current
  • Wilco One
    Foodtech & Agritech cohort
Affineo Affineo

Let's talk about what becomes possible when a protein keeps working where proteins usually don't.

Partnerships

Process, refining and formulation teams whose bottleneck is what a protein could bind, or where it could survive.

Investors

Seed and strategic investors with conviction in platform biotech and engineered proteins as industrial materials.

Reach the team contact@affineo.bio
4 rue Pierre Fontaine, 91000 Évry-Courcouronnes